Extragastrointestinal stromal tumors (EGISTs) are relatively rare soft tissue neoplasms arising from the extra gastrointestinal tract.
The current study presents a case of primary EGIST of the prostate observed in a 55-year-old male. Imaging studies showed a 10×10.5×9.5-cm prostate mass. On histological observation, the mass was separated from the rectum serosa and exhibited a high mitotic count (8/50 high-power fields). The results of immunohistochemical staining showed positive immunoreactivity for cluster of differentiation (CD)117 (c-kit), CD34 and DOG1 in the tumor. On mutation analysis, loss of heterozygosity of the c-kit gene was observed in the prostatic EGIST; however, the platelet-derived growth factor receptor-α (PDGFRA) gene was considered to be normal. Therefore, as EGIST of the prostate is rare, there is a requirement for the confirmation of the diagnosis to be based on immunohistochemistry and mutation analysis (of c-kit and PDGFRA).
Written by:
Liu S, Yu Q, Han W, Qi L, Zu X, Zeng F, Xie Y, Liu J. Are you the author?
Department of Urology, Xiangya Hospital, The Central South University, Changsha, Hunan 410008, P.R. China; Department of Urology, The Affiliated Tumor Hospital of Xiangya Medical School, The Central South University, Changsha, Hunan 410013, P.R. China; Department of Rheumatology, Ningbo Medical Center Li Huili Hospital, Ningbo, Zhejiang 315040, P.R. China; Department of Anesthesia, The Affiliated Tumor Hospital of Xiangya Medical School, The Central South University, Changsha, Hunan 410008, P.R. China.
Reference: Oncol Lett. 2014 Jun;7(6):1925-1929.
doi: 10.3892/ol.2014.1968
PubMed Abstract
PMID: 24932260
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