BACKGROUND: Men with a BRCA2 mutation face substantial lifetime risks for the development of both breast and prostate cancer.
INVESTIGATIONS: A male who was initially diagnosed with breast cancer at the age of 32 was was subsequently diagnosed at age 77 with both contralateral breast cancer and prostate cancer. He was found to be BRCA2 mutation carrier.
DIAGNOSIS: Hereditary multiple primary cancer in a male BRCA2 mutation carrier.
MANAGEMENT: The patient was treated with contralateral mastectomy, breast irradiation, prostate irradiation and adjuvant endocrine therapy. At age 83 he died of metastatic prostate cancer.
CONCLUSION: Our case underscores the observation that BRCA2 mutation carriers are at risk for multiple cancers, including contralateral breast cancer, and illustrates the need for current practice recommendations for the early detection of breast and prostate cancer in men with BRCA2 mutations.
Written by:
Singer CF, Rappaport-Fuerhauser C, Sopik V, Narod SA. Are you the author?
Department of OB/GYN, and Comprehensive Cancer Center, Medical University of Vienna, Austria.
Reference: Clin Genet. 2014 Aug 12. Epub ahead of print.
doi: 10.1111/cge.12478
PubMed Abstract
PMID: 25112434