Prostate cancer (PrCa) is the most commonly diagnosed cancer in the male UK population, with over 40,000 new cases per year. PrCa has a complex, polygenic predisposition, due to rare variants such as BRCA and common variants such as single nucleotide polymorphisms (SNPs). With the introduction of genome-wide association studies, 78 susceptibility loci (SNPs) associated with PrCa risk have been identified. Genetic profiling could risk-stratify a population, leading to the discovery of a higher proportion of clinically significant disease and a reduction in the morbidity related to age-based prostate-specific antigen screening. Based on the combined risk of the 78 SNPs identified so far, the top 1% of the risk distribution has a 4.7-times higher risk of developing PrCa compared with the average of the general population.
Written by:
Mikropoulos C, Goh C, Leongamornlert D, Kote-Jarai Z, Eeles R. Are you the author?
The Institute of Cancer Research, Sutton, Surrey, UK.
Reference: Future Oncol. 2014 Aug;10(9):1679-94.
doi: 10.2217/fon.14.72
PubMed Abstract
PMID: 25145435
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