Defined broadly, prostate cancer has two states: An indolent histological manifestation of a locally proliferative and invasive process or a clinically relevant, potentially lethal disease. Likewise, the management of clinically localized prostate cancer must address two questions: what sort of disease is this and what needs to be done.
The protean nature of prostate cancer, summarized in a simple question by Dr. Whitmore, is becoming increasingly relevant in current disease management. Defined broadly, prostate cancer has two states: an indolent histological manifestation of a locally proliferative and invasive process or a clinically relevant, potentially lethal disease. Likewise, the management of clinically localized prostate cancer must address two questions: what sort of disease is this and what needs to be done. Dissecting Whitmore’s conundrum – a riddle contained within a pun – is useful in structuring a perspective on clinically localized prostate cancer...
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Joel B. Nelson Are you the author?
Department of Urology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
Reference: Asian J Androl. 2014 Jul-Aug;16(4):511-4
doi: 10.4103/1008-682X.123672.
PubMed Abstract
PMID: 24589461