BACKGROUND: Adipose tissue is increasingly considered as an endocrinal active organ and may have an influence on the development and progression of prostate cancer.
Adverse body fat distribution, considered a risk factor for cardiovascular disease, is not reflected by the body mass index (BMI).
OBJECTIVE: The purpose of this work was to assess anthropometric indices which provide a better estimate of body fat distribution and to evaluate their association with clinical and histopathological parameters of prostate cancer.
PATIENTS AND METHODS: In patients scheduled for radical prostatectomy between March 2011 and March 2013, height, weight, waist circumference (WC) and hip circumference were measured, then the BMI, waist-to-hip ratio (WHR) and waist-to-height ratio (WHtR) were calculated. The relationships between anthropometric measures and indices and clinical and histopathological features of PCA were evaluated with uni- and multivariate analyses.
RESULTS: In 668 patients available for evaluation, obesity rates were 22.8 %, 50.6% and 30.2 % as defined by BMI ≥ 30, WHR ≥ 1 and WHtR ≥ 0.6, respectively. On univariate analysis, WC and WHtR ≥ 0.6 correlated with tumor volume (TV) > 2.1 cm2 (p < 0.05), respectively. WC and WHtR were independent predictors of a TV ≥ 2.1 cm2 (p < 0.05) and a WHtR ≥ 0.6 was an independent predictor of a TV ≥ 2.1 cm2 (p < 0.018, risk ratio 1.506, 95 % confidence interval 1.072-2.115).
CONCLUSION: In general a higher degree of adiposity seems to correlate with a higher tumor volume. Whether anthropometric indices have prognostic impact needs to be clarified during follow-up.
Written by:
Löppenberg B, Roghmann F, Brock M, von Bodmann C, Michels CJ, Noldus J, Palisaar J. Are you the author?
Klinik für Urologie, Marien-Hospital Herne, Klinikum der Ruhr-Universität Bochum, Widumerstraße 8, 44627, Herne, Deutschland.
Reference: Urologe A. 2015 Jan;54(1):22-7.
doi: 10.1007/s00120-014-3700-4
PubMed Abstract
PMID: 25503718
Article in German.