Radiotherapy and androgen deprivation therapy play a major role in the management of prostate cancer. Indeed, radiotherapy and hormone therapy are combined in a neoadjuvant and concomitant setting for intermediate risk cancers but also in an adjuvant setting in high risk or locally advanced prostate cancer. The benefice of this association was suggested by preclinical studies and demonstrated later by several randomized trials. However, as these trials were conducted before the era of dose escalation the role of androgen deprivation therapy in this case is less clear. Moreover, as hormonal therapy can lead to a significant morbidity and a decrement in quality of life its indications must be carefully weighed especially in case of intermediate risk cancer witch represent a heterogeneous group with distinct prognostic subgroups.
Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique. 2016 Mar 08 [Epub ahead of print]
S Bellefqih, K Hadadi, I Mezouri, A Maghous, E Marnouche, K Andaloussi, M Elmarjany, H Sifat, H Mansouri, N Benjaafar
Service de radiothérapie, centre régional d'oncologie, avenue Carabonita, 32002 Al Hoceima, Maroc. Electronic address: ., Service de radiothérapie, hôpital militaire d'instruction Mohamed-V, avenue Al Arz, 10100 Rabat, Maroc., Service de radiothérapie, centre d'oncologie Hassan-II, 8km route Jerada, 4806 Oujda, Maroc., Service de radiothérapie, hôpital militaire d'instruction Mohamed-V, avenue Al Arz, 10100 Rabat, Maroc; Service de radiothérapie, Institut national d'oncologie, avenue Allal El Fassi, 10100 Rabat, Maroc., Service de radiothérapie, hôpital militaire d'instruction Mohamed-V, avenue Al Arz, 10100 Rabat, Maroc; Service de radiothérapie, Institut national d'oncologie, avenue Allal El Fassi, 10100 Rabat, Maroc., Service de radiothérapie, hôpital militaire d'instruction Mohamed-V, avenue Al Arz, 10100 Rabat, Maroc., Service de radiothérapie, hôpital militaire d'instruction Mohamed-V, avenue Al Arz, 10100 Rabat, Maroc., Service de radiothérapie, hôpital militaire d'instruction Mohamed-V, avenue Al Arz, 10100 Rabat, Maroc., Service de radiothérapie, hôpital militaire d'instruction Mohamed-V, avenue Al Arz, 10100 Rabat, Maroc., Service de radiothérapie, Institut national d'oncologie, avenue Allal El Fassi, 10100 Rabat, Maroc.