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S6Ks isoforms contribute to viability, migration, docetaxel resistance and tumor formation of prostate cancer cells: Beyond the Abstract

In this research article we have studied the role of a family of proteins called S6Ks in prostate cancer cells. These proteins are effectors of the mTOR pathway, which is responsible to transduce signal from hormones and growth factors into cell growth and proliferation.

The mTOR pathway has an important function for cell homeostasis, but its role in several diseases, including cancer, has been reported. S6Ks are comprised of several isoforms, some of them are very well studied, others are poorly investigated. We have compared the role of different members of S6Ks in a prostate cancer cell model. We have found that both S6K1 and S6K2 genes overexpression are related to increase in viability, migration and docetaxel (a chemotherapeutic drug) resistance of prostate cancer cells in vitro.

Besides, these proteins presented a positive relation to tumor growth when overexpressed in vivo using a mouse model. Conversely, inhibition of those proteins reduced effects related to prostate cancer cells growth. Finally, we have tested an available inhibitor for S6K1, which has significantly reduced prostate cancer cells growth and may be potentially used in prostate cancer treatment in the future

Written by: Fernando Simabuco