Indications of kidney cancer outcome in lowerincome countries are based on an incidence/mortality ratio due to lack of survival information. This study was conducted to provide outcome data in Serbian patients with renal cell carcinoma (RCC) and to identify prognostic factors that could affect their overall survival (OS).
This retrospective study included 185 patients who underwent nephrectomy. We assessed certain clinicopathological data including age, gender, tumor size, grade, stage and histological subtypes for their possible impact on OS.
The 5-year OS was 63.2%. Significant association was found between OS and age (log-rank 12.455, p=0.006), tumor size (log-rank 26.425, p=0.000), grade (log-rank 13.249, p=0.000) and stage (log-rank 43.235, p=0.000). Univariate analysis indicated size (p=0.000), grade (p=0.001) and stage (p=0.000) as prognostic factors for OS. In multivariate analysis, grade (p=0.014) and stage (p=0.000) remained significant predictors of OS.
Tumor grade and stage were identified as independent prognostic factors of OS survival in Serbian patients with RCC.
Journal of B.U.ON. : official journal of the Balkan Union of Oncology. 0000 Jan [Epub]
Ivan Pavlovic, Snezana Pejic, Sofija Glumac, Ana Todorovic, Vesna Stojiljkovic, Natasa Popovic, Ljubica Gavrilovic, Snezana B Pajovic, Sanja Radojevic-Skodric, Zoran Dzamic, Gordana Basta-Jovanovic
Laboratory of Molecular Biology and Endocrinology, "Vinca" Institute of Nuclear Sciences, University of Belgrade, Belgrade, Serbia.