There are few data on Bacillus Calmette-Guérin (BCG) therapy for upper urinary tract carcinoma in situ (UUT CIS). We retrospectively evaluated the efficacy and tolerability of BCG therapy for 41 patients [52 renal units(RUs)] with UUT CIS. Of 52 RUs, complete response was achieved in 47 (90%). The 5-year recurrence-, progression-free survival rates were 60.2% and 74.2%, respectively. Adverse events were observed in 31 (76%) patients, but most of them were mild. The scheduled instillations were completed in 31 (74%) of 42 patients. Our results demonstrated that BCG therapy for UUT CIS was satisfactory with high efficacy and tolerability.
Cancer investigation. 2018 Feb 02 [Epub ahead of print]
Ikko Tomisaki, Tatsuhiko Kubo, Akinori Minato, Naohiro Fujimoto
a Department of Urology , University of Occupational and Environmental Health , 1-1 Iseigaoka Yahatanishi-ku Kitakyushu City Fukuoka , Japan., b Department of Public Health , University of Occupational and Environmental Health , 1-1 Iseigaoka Yahatanishi-ku Kitakyushu City Fukuoka , Japan.