Bosniak category III renal cystic masses are often treated with surgical resection because of high risk of malignancy. Crizotinib is an anaplastic lymphoma kinase (ALK) inhibitor used to treat ALK gene-rearranged non-small cell lung cancer (NSCLC) and reported to be associated with complex renal cyst formation. We herein report a case of Bosniak category III renal cysts occurred in a crizotinib-treated ALK gene-rearranged NSCLC patients. The cysts regressed spontaneously after cessation of crizotinib and we could thus avoid unnecessary surgical resection.
Urology. 2018 Aug 21 [Epub ahead of print]
Kazuki Okubo, Akinori Sato, Keitaro Nakamoto, Yuki Hatanaka, Makoto Isono, Mina Hatanaka, Yosuke Suyama, Hiroshi Shinmoto, Tomohiko Asano
Department of Urology, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama 359-8513, Japan., Department of Urology, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama 359-8513, Japan. Electronic address: ., Department of Respiratory medicine, Fukujuji hospital, 3-1-24 Matsuyama, Kiyose, Tokyo 204-8522, Japan., Department of Radiology, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama 359-8513, Japan.