Acrylamide, an industrial chemical and probable human carcinogen, can be formed in primarily carbohydrate-containing foods during high heat cooking or processing. Most epidemiological studies show no associations of dietary acrylamide intake with most cancer outcomes, but limited prospective evidence suggests a positive association with renal cell carcinoma (RCC).
In 1999, 102,154 men and women from the Cancer Prevention Study-II Nutrition Cohort completed a questionnaire on diet, lifestyle and cancer risk factors and were followed through June 30, 2013. Cox proportional hazards regression was used to estimate the hazard ratio (HR) and 95% confidence interval (CI) for the association between estimated dietary acrylamide intake and risk of RCC.
After 1,137,441 person-years of follow-up, 412 cases of invasive RCC occurred. In multivariable adjusted models, there was no association between acrylamide intake and risk of RCC (HR=1.09, 95% CI 0.82-1.43) for the highest vs. lowest quartile of intake. Associations were not modified by sex or smoking history.
We found no associations between dietary acrylamide exposure and risk of invasive RCC.
Findings from this large, prospective analysis do not support a positive association between higher dietary acrylamide intake and RCC risk.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 2018 Nov 12 [Epub ahead of print]
Marjorie L McCullough, Rebecca A Hodge, Caroline Y Um, Susan M Gapstur
Behavioral and Epidemiology Research Group, American Cancer Society ., Behavioral and Epidemiology Research Group, American Cancer Society.