Approximately 70% of cases of kidney cancer are localized or locally advanced at diagnosis. Among patients who undergo surgery for these cancers, 30-35% will eventually develop potentially fatal metachronous distant metastases. Effective adjuvant treatments are urgently needed to reduce the risk of recurrence of kidney cancer and of dying of metastatic disease. To date, almost all of the tested adjuvant agents have failed to demonstrate any benefit. Only two trials of an autologous renal tumour cell vaccine and of the vascular endothelial growth factor receptor (VEGFR) tyrosine kinase inhibitor sunitinib have shown positive results, but these have been criticized for methodological reasons and conflicting data, respectively. The results of two additional trials of targeted agents as adjuvant therapies have not yet been published. Novel immune checkpoint inhibitors are promising approaches to adjuvant therapy in kidney cancer, and a number of trials are now underway. An important component of the management of patients with kidney cancer, particularly those who undergo radical resection for localized renal cell carcinoma, is the preservation of kidney function to reduce morbidity and mortality. The optimal management of these patients therefore requires a multidisciplinary approach involving nephrologists, oncologists, urologists and pathologists.
Nature reviews. Nephrology. 2019 Mar 26 [Epub ahead of print]
Camillo Porta, Laura Cosmai, Bradley C Leibovich, Thomas Powles, Maurizio Gallieni, Axel Bex
Department of Internal Medicine, University of Pavia, Pavia, Italy. ., Division of Nephrology, A.S.S.T. Santi Paolo e Carlo, San Carlo Borromeo Hospital, Milan, Italy., Department of Urology, Mayo Clinic, Rochester, MN, USA., Barts Cancer Institute Experimental Medicine Centre, Queen Mary University of London St Bartholomew's Hospital, London, UK., Department of Urology, Netherlands Cancer Institute, Amsterdam, Netherlands.