Prognostic Value of High CXCR4 Expression in Renal Cell Carcinoma: A System Review and Meta-Analysis
METHODS: Relevant studies focused on the relationship between high CXCR4 expression and the outcome of RCC were searched in PubMed and EMBASE/Cochrane Library database. Hazard ratios (HRs) of overall survival (OS) and progression-free survival (PFS) were our evaluation index. The individual and pooled HRs with 95% confidence intervals (CIs) were analyzed.
RESULTS: A total of 1068 patients from 7 studies were included in our meta-analysis. The results suggested that high CXCR4 expression predicted a poor OS (random effect model (REM) HR = 2.77, 95% CI = 1.80−4.27) and PFS (REM HR = 4.83, 95% CI = 2.30−10.15) for RCC patients.
CONCLUSION: The results of meta-analysis indicated that high CXCR4 expression was correlated with worse OS and PFS for patients with RCC. However, some larger samples and well-matched studies should be designed to estimate the potential prognosis of RCC patients.
Disease Markers, vol 2015, article ID 568980. 21 June 2015 [Epub]
Yuefeng Du1, Qingzhi Long2, Bing Guan2, and Lijun Mu2
1. Department of Urology, First Affiliated Hospital of Medical School, Xi’an Jiaotong University, Xi’an, Shanxi, China, China
2. Department of Urology, First Affiliated Hospital of Medical School, Xi’an Jiaotong University, China
Disease Markers; http://dx.doi.org/10.1155/2015/568980