To compare the functional outcomes of patients who underwent partial (PN) or radical nephrectomy (RN) for clinical T1 (cT1) renal tumors using the Kidney Cancer Database of the Urooncology Association, Turkey.
We retrospectively reviewed 1004 patients who underwent PN and RN for cT1 renal tumors at multiple academic tertiary centers between 2000 and 2018. Patients with preoperative end-stage chronic kidney disease and/or metastatic disease were excluded.
There were 452 patients in the PN group and 552 patients in the RN group. The median follow-ups were 74.9 and 83.7 months in RN and PN cohort. The eGFR was significantly reduced in both groups on postoperative day one (PN=13.7 vs. RN=19.1 ml/min/1.73 m2: p<0.001). In the PN group, eGFR showed a tendency to recover according to a quadratic pattern and reached preoperative levels in the first and third years (95.6±28.8 ml/min/1.73 m2 and 96.9±28.9 ml/min/1.73 m2, respectively), with no significant difference between the eGFRs in the 1st and 3rd years (p=0.710). To define groups at risk, different cut-off values for the GFR were considered. Among patients with a baseline GFR<90, the RN cohort had significantly lower eGFRs in the first and third years than the PN cohort (p=0.02). Logistic regression showed that comorbidities, coronary artery disease, diabetes, and hypertension had no adverse impacts on the changes in the eGFR (p=0.60, p=0.13, and p=0.13, respectively).
For the treatment of stage T1 kidney tumors, open or laparoscopic partial nephrectomy has the benefit to preserve renal function.
International journal of clinical practice. 2021 Jan 04 [Epub ahead of print]
Volkan İzol, Fatih Gökalp, Sinan Sözen, Ender Özden, Yıldırım Bayazıt, Talha Muezzinoğlu, Onder Kara, Serhat Çetin, Murat Gülşen, Levent Türkeri, Mustafa Zühtü Tansug, Kidney Cancer Study Group of Urooncology Association, Turkey
Department of Urology, Faculty of Medicine, Çukurova University, Adana, Turkey., Department of Urology, Faculty of Medicine, Mustafa Kemal University, Turkey., Department of Urology, Faculty of Medicine, Gazi University, Ankara, Turkey., Department of Urology, Faculty of Medicine, Ondokuz Mayıs University, Samsun, Turkey., Department of Urology, Faculty of Medicine, Manisa Celal Bayar University, Manisa, Turkey., Department of Urology, Faculty of Medicine, Kocaeli University, Turkey., Department of Urology, M. A. Aydınlar Acibadem University, Istanbul, Turkey.