The treatment for metastatic renal cell carcinoma (mRCC) has significantly evolved in recent years with a deeper understanding of the molecular make-up of the disease and the clinical development of therapies with novel mechanisms of action. While some patients with more indolent disease may benefit from local therapy such as metastasectomy or cytoreductive nephrectomy, others may safely embark on an active surveillance program or be offered targeted therapy. Yet, a combination regimen including an ICI is the most effective regimen and should be considered in most mRCC cases. Ongoing studies will help determine which factors can be further used to optimize treatment selection and personalize disease management.
Current treatment options in oncology. 2021 Jan 12*** epublish ***
Bryce R Christensen, Yasmin M Hajja, Vadim Koshkin, Pedro C Barata
Tulane University School of Medicine, 1415 Tulane Ave, New Orleans, LA, 70112, USA., University of California, 1825 Fourth St Sixth Floor, San Francisco, CA, 94158, USA., Tulane University School of Medicine, 1415 Tulane Ave, New Orleans, LA, 70112, USA. .