Aim: To assess symptoms, healthcare resource utilization and health-related quality of life in advanced renal cell carcinoma (aRCC) clinical practice. Materials & methods: The USA point-in-time survey of physicians and patients was conducted between February and September 2019. Results: Data were available for 227 patients. Mean (standard deviation) number of symptoms was 3.4 (3.2); differences were observed across International Metastatic RCC Database Consortium risk categories (p < 0.001), with fewer symptoms in favorable-risk patients. Disease burden, measured by greater healthcare resource utilization and worse health-related quality of life, was high, particularly in International Metastatic RCC Database Consortium intermediate- or poor- versus favorable-risk patients. In total, 45 patients (21.6%) were hospitalized due to aRCC within a 6-month period, 35 (16.8%) had one hospitalization and ten (4.8%) experienced ≥2 hospitalizations due to aRCC. Mean (standard deviation) 19-Item Functional Assessment of Cancer Therapy Kidney Symptom Index score was 53.6 (13.2) for this population, significantly lower than the reference value (59.8; p < 0.001). Conclusion: A clear need exists for improved disease management in patients with aRCC.
Future oncology (London, England). 2021 Feb 26 [Epub ahead of print]
Jennifer Hall, Giovanni Zanotti, Ruth Kim, Stan Krulewicz, Andrea Leith, Abigail Bailey, Frank X Liu, Mairead Kearney
Adelphi Real World, Adelphi Mill, Grimshaw Lane, Bollington, Macclesfield, SK10 5JB, UK., Pfizer, 235 E 42nd St, NY 10017, USA., Pfizer, 500 Arcola Road, Collegeville, PA 19426, USA., EMD Serono, Inc., 1 Technology Place, Rockland, MA 02370, USA; an affiliate of Merck KGaA, Darmstadt, 64293, Germany., Merck KGaA, Frankfurter Strasse 250, Darmstadt, 64293, Germany.