Cytoreductive nephrectomy and exposure to sunitinib - a post-hoc analysis of the SURTIME trial.

To analyze if exposure to sunitinib in the SURTIME trial which investigated opposite sequences of cytoreductive nephrectomy (CN) and systemic therapy is associated with the overall survival (OS) benefit observed in the deferred CN arm.

A post-hoc analysis of SURTIME trial data. Variables analysed included number of patients receiving sunitinib, time from randomisation to start sunitinib, overall response rate (ORR) by RECIST 1.1, and duration of drug exposure and dose in the intention-to-treat population of the immediate and deferred arm. Descriptive methods and 95% confidence-intervals (CI) were used.

In the deferred arm, 97.7%(CI:89.3-99.6; n=48) received sunitinib versus 80% (CI:66.9-88.7,n=40) in the immediate arm. Following immediate CN, 19.6% progressed 4 weeks after CN and median time to start sunitinib was 39.5 days versus 4.5 days in the deferred arm. At week 16, 46.0% had progressed at metastatic sites in the immediate CN arm versus 32.7% in the deferred arm. Sunitinib dose reductions, escalations and interruptions were not statistically significantly different between arms. Among patients who received sunitinib in the immediate or deferred arm the median total sunitinib treatment duration was 172.5 versus 248 days. Reduction of target lesions was more profound in the deferred arm.

In comparison to the deferred CN approach, immediate CN impairs administration, onset, and duration of sunitinib. Starting with systemic therapy leads to early and more profound disease control and identification of progression prior to planned CN which may have contributed to the observed OS benefit.

BJU international. 2021 Oct 27 [Epub ahead of print]

Yasmin Abu-Ghanem, Johannes V van Thienen, Christian Blank, Maureen J B Aarts, Michael Jewett, Igle Jan de Jong, J B Lattouf, Harm H E van Melick, Lori Wood, Peter Mulders, Sylvie Rottey, John Wagstaff, Patricia Zondervan, Tom Powles, Anouk Neven, Laurence Collette, Bertrand Tombal, John Haanen, Axel Bex

Royal Free London NHS Foundation Trust and UCL Division of Surgery and Interventional Science, London., Netherlands Cancer Institute, Amsterdam., Maastricht University Medical Center, Maastricht., Princess Margaret Hospital, Toronto., University of Groningen, University Medical Center Groningen., University of Montreal Hospital Center, Montreal., Saint Antonius Hospital, Nieuwegein., QEII Health Sciences Center, Halifax., Radboud University Hospital, Nijmegen., Ghent University Hospital, Ghent., South West Wales Cancer Centre and Swansea University College of Medicine., University Medical Centers, Amsterdam., Barts and Queen Mary University London., European Organisation of Research and Treatment of Cancer (EORTC), Brussels.