A comprehensive evaluation of the clear cell renal cell carcinoma (ccRCC) immune landscape was found using 584 RNA-sequencing datasets from The Cancer Genome Atlas (TCGA), we identified 17 key dysregulated immune-associated genes in ccRCC based on association with clinical variables and important immune pathways. Of the numerous findings from our analyses, we found that several of the 17 key dysregulated genes are heavily involved in interleukin and NF-kB signaling and that somatic copy number alteration (SCNA) hotspots may be causally associated with gene dysregulation. More importantly, we also found that key immune-associated genes and pathways are strongly upregulated in ccRCC. Our study may lend novel insights into the clinical implications of immune dysregulation in ccRCC and suggests potential immunotherapeutic targets for further evaluation.
Neoplasia (New York, N.Y.). 2022 Jan 03 [Epub ahead of print]
Omar A Saad, Wei Tse Li, Aswini R Krishnan, Griffith C Nguyen, Jay P Lopez, Rana R McKay, Jessica Wang-Rodriguez, Weg M Ongkeko
Department of Surgery, University of California, San Diego, La Jolla, CA 92093, USA. Electronic address: ., Department of Surgery, University of California, San Diego, La Jolla, CA 92093, USA. Electronic address: ., Department of Surgery, University of California, San Diego, La Jolla, CA 92093, USA. Electronic address: ., Department of Surgery, University of California, San Diego, La Jolla, CA 92093, USA. Electronic address: ., Division of Hematology and Oncology, New York-Presbyterian/Weill Cornell Medical College, NY, USA., Department of Medicine, Division of Hematology/Oncology, University of California San Diego, San Diego, CA, USA. Electronic address: ., Veterans Administration Medical Center and Department of Pathology, University of California, San Diego, La Jolla, California 92161, USA. Electronic address: ., Department of Surgery, University of California, San Diego, La Jolla, CA 92093, USA. Electronic address: .