The tyrosine-protein kinase c-Met plays a decisive role in numerous cellular processes, as a proto-oncogene that supports aggressive tumor behavior. It is still unknown whether c-Met could be relevant for prognosis of papillary RCC (pRCC).
Specimen collection were a collaboration of the PANZAR consortium. Patients' medical history and tumor specimens were collected from n=197 and n=110 patients with type 1 and 2 pRCC, respectively. Expression of cMET was determined by immunohistochemistry (IHC).
In total, cMET staining was evaluable in of 97/197 type 1 and 63/110 type 2 of pRCC cases. Five-years overall survival reviled no significant difference in dependence of cMET positivity (cMET- vs. cMET+: pRCC type 1: 84.8 % vs. 80.3 %, respectively (p=0.303, log-rank); type 2: 71.4 % vs. 64.4 % respectively (p= 0.239, log-rank)). Interestingly, the subgroup analyses showed a significant difference for cMET expression in T stage and metastases of the pRCC type 2 (p=0.014, p=0.022, chi-square). The cMET positive type 2 collective developed more metastases compared to the cMET negative cohort (pRCC Typ 2 M+: cMET-: 2 (4.3%) vs. cMET+: 12 (19%)).
CMET expression did not qualify as a prognostic marker in pRCC for overall survival.
Human pathology. 2022 Jan 05 [Epub ahead of print]
Franziska Erlmeier, Benedict Bruecher, Christine Stöhr, Edwin Herrmann, Iris Polifka, Abbas Agaimy, Lutz Trojan, Philipp Ströbel, Frank Becker, Christian Wülfing, Peter Barth, Michael Stöckle, Michael Staehler, Christian Stief, Axel Haferkamp, Markus Hohenfellner, Stephan Macher-Göppinger, Bernd Wullich, Joachim Noldus, Walburgis Brenner, Frederik C Roos, Bernhard Walter, Wolfgang Otto, Maximilian Burger, Andres Jan Schrader, Arndt Hartmann, Yvonne Mondorf, Philipp Ivanyi, Marie Mikuteit, Sandra Steffens, German Network Of Kidney Cancer
Institute of Pathology, University Hospital Erlangen-Nuernberg, Friedrich Alexander University (FAU), 91054 Erlangen, Germany . Electronic address: ., Department of Urology, University Hospital Muenster, 48149 Muenster, Germany ., Institute of Pathology, University Hospital Erlangen-Nuernberg, Friedrich Alexander University (FAU), 91054 Erlangen, Germany ., Department of Urology, University Hospital Göttingen, 37075 Göttingen, Germany ., Department of Pathology, University Hospital Göttingen, 37075 Göttingen, Germany ., Department of Urology and Pediatric Urology, University of Saarland (UKS), 66421 Homburg, Germany ., Department of Urology, University of Marburg, 35037 Marburg, Germany ., Department of Urology, University Hospital Munich, 81337 Munich, Germany ., Department of Urology, University Hospital Heidelberg, 69120 Heidelberg, Germany ., Institute of Pathology, University Hospital Mainz, 55131 Mainz, Germany ., Department of Urology and Pediatric Urology, University Hospital Erlangen, Friedrich Alexander University (FAU), 91058 Erlangen, Germany ., Department of Urology, Marien Hospital Herne, Ruhr University Bochum, 44625 Herne, Germany., Department of Urology, University of Mainz, 55131 Mainz, Germany ., Department of Urology, University Hospital Frankfurt, 60590 Frankfurt/Main, Germany ., Department of Urology, University of Regensburg, 93053 Regensburg, Germany ., Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, 30625 Hannover, Germany., Hannover Medical School: Medizinische Hochschule Hannover, Hannover, Germany.