The aim of this study was to investigate the prognostic significance of the preoperative neutrophil-to-lymphocyte ratio in non-metastatic renal cell carcinoma.
We retrospectively analyzed the records of patients with non-metastatic renal cell carcinoma who were operated between 2004 and 2020 at our institution. The Kaplan-Meier method was utilized to graphically display survivor functions. Univariate and multivariate Cox's proportional hazards regression models were utilized to analyze the association between neutrophil-to-lymphocyte ratio and oncological outcomes.
We included 202 patients. Patients with higher neutrophil-to-lymphocyte ratio had larger tumors (P=0.03), higher ASA score (P=0.014), clinical symptoms (P=0.04), sarcomatoid differentiation (P=0.03) and tumor necrosis (P=0.02). The rates of recurrence-free survival and metastasis-free survival were significantly lower in patients with a high neutrophil-to-lymphocyte ratio than in those with a low ratio (P=0.017; P=0.036 respectively). Multivariate analysis identified the neutrophil-lymphocyte ratio as an independent predictor of recurrence-free and metastasis-free survival (P=0.021; P=0.001 respectively).
A higher neutrophil-to-lymphocyte ratio has been associated with a symptomatic renal cancer with a significant prognostic factor for both recurrence-free and metastasis-free survival.
3.
Progres en urologie : journal de l'Association francaise d'urologie et de la Societe francaise d'urologie. 2022 May 20 [Epub ahead of print]
Kays Chaker, Yassine Ouanes, Kheireddine Mourad Dali, Mokhtar Bibi, Yosri Messaoudi, Boutheina Mosbehi, Karem Abid, Ahmed Sellami, Sami Ben Rhouma, Yassine Nouira
Service d'urologie, hôpital la Rabta, université de Tunis El Manar, Tunis, Tunisie. Electronic address: ., Service d'urologie, hôpital la Rabta, université de Tunis El Manar, Tunis, Tunisie., Service d'anesthésie réanimation, hôpital la Rabta, université de Tunis El Manar, Tunis, Tunisie.