Percutaneous ablation therapy (AT) and partial nephrectomy (PN) are successful management strategies for T1a renal cancer. Our objective was to compare AT to PN with respect to recurrence-free survival (RFS) and overall survival (OS).
Patients post PN or AT for cT1aN0M0 renal cancer from 2011 - 2021 were identified from the national Canadian Kidney Cancer Information System (CKCis). Inverse probability of treatment weighting (IPTW) using propensity scores (PS) was used. The primary outcomes, RFS and OS, were compared using Kaplan-Meier log rank test analyses and Cox proportional hazard regression models.
275 patients underwent AT and 2,001 underwent PN, with a median follow-up of 2.0 years (IQR 0.6-4.1 years). Covariates were well balanced between the AT and PN cohorts following PS matching. Two-year RFS following IPTW PS analysis for patients undergoing AT and PN was 88.1% and 97.4% (p<0.0001) respectively, while two-year OS was 97.4% and 99.0% (p=0.7), respectively. Five-year RFS following IPTW PS analysis for patients undergoing AT and PN was 86.0% and 95.1% respectively (p=0.003), while five-year OS was 94.2% and 95.1%, respectively (p=0.9). Following IPTW PS analysis, treatment modality (PN versus AT) was a predictor for disease recurrence (HR 0.36; p=0.003) but not for overall survival (HR 0.96; p=0.9).
With short follow-up, PN offers better RFS than AT, although no significant difference in overall survival was detected following propensity score adjustments. Both modalities can be offered to appropriately selected patients while we await a prospective randomized data.
The Journal of urology. 2022 Jun 10 [Epub ahead of print]
Braden Millan, Rodney H Breau, Bimal Bhindi, Ranjeeta Mallick, Simon Tanguay, Antonio Finelli, Luke T Lavallée, Frédéric Pouliot, Ricardo Rendon, Alan I So, Lucas Dean, Jean-Baptiste Lattouf, Naveen S Basappa, Anil Kapoor
Division of Urology, McMaster Institute of Urology, McMaster University, Hamilton, Ontario, Canada., Division of Urology, University of Ottawa, Ottawa, Ontario, Canada., Division of Urology, University of Calgary, Calgary, Alberta, Canada., School of Epidemiology and Public Health, University of Ottawa, Ottawa, Ontario, Canada., Division of Urology, McGill University, Montreal, Quebec, Canada., Division of Urology, University of Toronto, Toronto, ON, Canada., Department of Surgery, Division of Urology, Université Laval, Quebec City, QC, Canada., Department of Urology, Dalhousie University, Halifax, NS, Canada., Department of Urologic Sciences, The University of British Columbia, Vancouver, BC, Canada., Department of Surgery, Alberta Urology Institute Research Center, University of Alberta, Edmonton, Alberta, Canada., Department of Surgery, University of Montreal, Montreal, QC, Canada., Department of Oncology, University of Alberta, Cross Cancer Institute, Edmonton, AB, Canada.