A Systematic Review of Immune Checkpoint Inhibitors in Non-Clear-Cell Renal Cancer.

Immune checkpoint inhibitors (ICI) have emerged as active therapies in the management of advanced RCC. While multiple studies have shown clinical activity of ICIs in clear cell histologies, the evidence to support their use in non-clear cell (ncc) subtypes is based on smaller prospective trials and retrospective analyses.

The objective of this review is to summarize the clinical outcomes of ICI-based therapies in ncc-subtypes and in tumors with sarcomatoid/rhabdoid features.

We performed a systematic literature search using PubMed, Google Scholar and ASCO databases. The keywords "renal cell cancer" and "immune checkpoint inhibitors" and equivalents were used and all original publications between July 2016 and July 2021 were included.

We included a total of 14 publications, including two clinical trials and 12 case series. The most frequent histologies were papillary (up to 75-100%), unclassified (up to 34%) and chromophobe (up to 28%). ICI monotherapy showed some activity in both 1st and 2nd line with response rates up to 27%. ICI combination regimens yielded better activity than ICI monotherapy but, overall, a heterogeneous efficacy was noted across histologies. Overall, outcomes of ICIs were superior in tumors with sarcomatoid/rhabdoid features.

The observed activity of ICI-based therapies was heterogeneous. Combination regimens, papillary subtype and sarcomatoid/rhabdoid features were associated with higher responses. These findings might help treatment decisions and require further validation.

Kidney cancer (Clifton, Va.). 2022 Aug 04*** epublish ***

Ana Filipa Palma Dos Reis, Diana Simão, Thomas Odeny, Chiara Rodrigues, Mário Fontes-Sousa, Ricardo da Luz, Rajasree Pia Chowdry, Sarah J Welsh, Channing Paller, Pedro C Barata

Department of Medical Oncology, Centro Hospitalar Universitário de Lisboa Central, Lisbon, Portugal., National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., Department of Medical Oncology, CUF TEJO, Lisbon, Portugal., Department of Medicine, Section of Hematology/Oncology, Louisiana State University, New Orleans, LA, USA., Department of Medical Oncology, Addenbrookes Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., Department of Medical Oncology, Johns Hopkins School of Medicine, Baltimore, MD, USA., Deming Department of Medicine, Hematology/Oncology Section, Tulane Medical School, New Orleans, LA, USA.