The standard treatment for renal cell carcinoma (RCC) is surgery. However, a number of patients will not be candidates for surgical treatment or will reject this therapeutic approach. Therefore, alternative approaches are required.
Historically, radiotherapy has been considered an ineffective treatment for RCC due to the radioresistance of renal tumour cells to conventional fractionation and the increased rate of toxicity. Stereotactic body radiotherapy (SBRT) is a radiotherapy technique that provides a non-invasive ablative treatment with remarkable rates of local control in both primary tumours and metastases in several locations, with a low associated morbidity due to the highly conformal dose and the use of image-guided techniques. Current evidence shows that a higher dose per fraction, achieving a higher biological effective dose, can overcome the radioresistance of RCC cells. Therefore, SBRT, as well as the combination of SBRT and new emerging immune therapies, has a potential role in the local treatment of primary RCC and oligometastatic RCC patients.
Clinical oncology (Royal College of Radiologists (Great Britain)). 2022 Nov 25 [Epub ahead of print]
E Carrasco-Esteban, P Barrionuevo-Castillo, J Domínguez-Rullán, M A Gómez-Aparicio, M Ferri-Molina, P Sáez-Bueno, Z Zalabarría-Zarrabeitia, M Scorsetti, S Arcangeli, F López-Campos, F Couñago
Department of Radiation Oncology, Hospital Central de la Defensa Gómez Ulla, Madrid, Spain., Department of Radiation Oncology, Complejo Hospitalario de Jaén, Jaén, Spain., Department of Radiation Oncology, Hospital Universitario Ramón y Cajal, Madrid, Spain., Department of Radiation Oncology, Hospital Universitario de Toledo, Toledo, Spain., Department of Radiation Oncology, Hospital Universitario Marqués de Valdecilla, Santander, Spain., Department of Radiotherapy and Radiosurgery, IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy., UOC Radioterapia ASST Monza, Università di Milano, Bicocca, Italy., Department of Radiation Oncology, Hospital Universitario Ramón y Cajal, Madrid, Spain. Electronic address: ., Department of Radiation Oncology, Hospital Universitario Quirónsalud Madrid, Pozuelo, Madrid, Spain; Universidad Europea de Madrid (UEM), Madrid, Spain.
PubMed http://www.ncbi.nlm.nih.gov/pubmed/36443137