To evaluate the significance of both low and high body mass index (BMI) as a biomarker in first-line tyrosine kinase inhibitors (TKIs) for metastatic renal cell carcinoma (mRCC).
The oncological outcome of 235 patients with mRCC treated with TKI from 2007 to 2018 was reviewed retrospectively. All patients received first-line TKI as therapy. We analyzed the relationship between BMI (low and high) and disease control rate. The primary outcome was progression free survival and overall survival, and the association between BMI and survival prognosis was evaluated.
The median BMI was 22.5 kg/m2 , and 25 patients (10.7%) had a low BMI (<18.5 kg/m2 ), 158 patients (67.2%) had a normal BMI (18.5-25 kg/m2 ), and 52 patients (22.1%) had a high BMI (≥ 25 kg/m2 ). Patients in the low BMI group had a significantly lower disease control rate, whereas patients in the high BMI group had a significantly higher disease control rate (p = 0.002 and p = 0.030, respectively). A log-rank test showed prognosis to be significantly poorer in the low BMI group and to be significantly better in the high BMI group than that in the normal BMI group. Multivariable Cox regression analysis showed that low BMI was an independent indicator of poor prognosis, whereas high BMI was an independent indicator of favorable prognosis.
We showed the impact of both low and high BMI on predicting therapeutic efficacy and prognosis in mRCC patients treated with TKI.
International journal of urology : official journal of the Japanese Urological Association. 2022 Nov 30 [Epub ahead of print]
Kenshiro Takemoto, Yohei Sekino, Hiroyuki Kitano, Kenichiro Ikeda, Keisuke Goto, Keisuke Hieda, Tetsutaro Hayashi, Yasuhisa Hasegawa, Masao Kato, Yuichi Kadonishi, Mitsuru Kajiwara, Jun Teishima, Koji Mita, Satoshi Maruyama, Masanobu Shigeta, Nobuyuki Hinata
Department of Urology, Graduate School of Biomedical and Health Science, Hiroshima University, Hiroshima, Japan., Department of Urology, Fukuyama Medical Center, Fukuyama, Japan., Department of Urology, Hiroshima General Hospital, Hatsukaichi, Japan., Department of Urology, Onomichi General Hospital, Onomichi, Japan., Department of Urology, Hiroshima Prefectural Hospital, Hiroshima, Japan., Department of Urology, Hiroshima-City Asa Citizens Hospital, Hiroshima, Japan., Department of Urology, Miyoshi Central Hospital, Miyoshi, Japan., Department of Urology, Kure Medical Center and Chugoku Cancer Center, Kure, Japan.