There is a lack of cheap and effective biomarkers for the prediction of renal cancer outcomes post-image-guided ablation. This is a retrospective study of patients with localised small renal cell cancer (T1a or T1b) undergoing cryoablation or radiofrequency ablation (RFA) at our institution from 2003 to 2016. A total of 203 patients were included in the analysis. In the multivariable analysis, patients with raised neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) pre-operatively, post-operatively and peri-operatively are associated with significantly worsened cancer-specific survival, overall survival and metastasis-free survival. Furthermore, an increased PLR pre-operatively is also associated with increased odds of a larger than 25% drop in renal function post-operatively. In conclusion, NLR and PLR are effective prognostic factors in predicting oncological outcomes and peri-operative outcomes; however, larger external datasets should be used to validate the findings prior to clinical application.
Cancers. 2023 Apr 06*** epublish ***
Aqua Asif, Vinson Wai-Shun Chan, Filzah Hanis Osman, Jasmine Sze-Ern Koe, Alexander Ng, Oliver Edward Burton, Jon Cartledge, Michael Kimuli, Naveen Vasudev, Christy Ralph, Satinder Jagdev, Selina Bhattarai, Jonathan Smith, James Lenton, Tze Min Wah
Royal Surrey NHS Foundation Trust, Surrey GU2 7XX, UK., Division of Surgery and Interventional Science, University College London, London WC1E 6BT, UK., School of Medicine, Faculty of Medicine and Health, University of Leeds, Leeds LS2 9JT, UK., Chesterfield Royal Hospital NHS Foundation Trust, Chesterfield S44 5BL, UK., School of Medical Education, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE1 7RU, UK., Department of Urology, St. James's University Hospital, Leeds LS9 7TF, UK., Department of Medical Oncology, St. James's University Hospital, Leeds LS9 7TF, UK., Department of Pathology, St. James's University Hospital, Leeds LS9 7TF, UK., Department of Diagnostic and Interventional Radiology, Institute of Oncology, Leeds Teaching Hospitals Trust, St. James's University Hospital, Leeds LS9 7TF, UK., Leeds Institute of Medical Research, University of Leeds, Leeds LS2 9JT, UK.