Immunotherapy has proven effective in metastatic renal cell carcinoma (RCC). The current standard of treatment in localized RCC is partial or complete nephrectomy. However, after surgery, there is a high recurrence rate and survival rates ranging from 53% to 85% depending on the stage of disease at presentation. Given clinical response to immunotherapies in metastatic RCC, these therapies are being tested as monotherapy and in combination with vascular endothelial growth factor receptor tyrosine kinase inhibitors in the (neo)adjuvant setting. Here we describe the current landscape of these treatments in localized RCC.
Therapeutic advances in medical oncology. 2023 Jul 29*** epublish ***
Jasmeet Kaur, Goutham Patil, Daniel M Geynisman, Pooja Ghatalia
Department of Hematology/Oncology, Fox Chase Cancer Center, Philadelphia, PA, USA., Trinity Health Oakland Hospital, Pontiac, MI, USA., Department of Hematology/Oncology, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA.