We aimed to retrospectively investigate whether the neutrophil to lymphocyte ratio (NLR) and the monocyte to lymphocyte ratio (MLR) can predict the prognosis of patients with metastatic renal cell carcinoma (mRCC) treated with sunitinib or sorafenib.
We retrospectively identified 210 patients with mRCC treated with sunitinib or sorafenib from 2007 to 2017 at Fudan University- and Hexi University-affiliated hospitals. Overall survival (OS) and progression-free survival (PFS) were evaluated using the Kaplan-Meier method. Multivariate regression analysis was used to evaluate predictors of PFS and OS.
Low NLR (<2.85) and MLR (<.30) were strongly associated with increased PFS and OS. Multivariable analyses verified that the NLR and MLR were both independent prognostic factors. Additionally, the NLR was negatively correlated with CD8+ and CD4+ T-cell infiltration in tumors.
In patients with mRCC treated with sunitinib and sorafenib, an NLR <2.85 and MLR <.30 was associated with superior PFS and OS, which may be related to the reduced lymphocytic infiltration of tumors.
Cancer control : journal of the Moffitt Cancer Center. 2023 Dec [Epub]
Zhaojuan Wang, Yujie Qin, Xuxia Chai, Lina Lu, Ping Xue, Runrun Lu, Chengrui Miao, Haimei Ma, Xiaoyi Hu, Jiaxi Yao
Department of Pharmacy, Hexi University Affiliated Zhangye People's Hospital, Zhangye, China., Department of Endoscopy Center, Hexi University Affiliated Zhangye People's Hospital, Zhangye, China., Department of Laboratory, Hexi University Affiliated Zhangye People's Hospital, Zhangye, China., Hexi University School of Medicine, Zhangye, China., Department of Urology, Zhongshan Hospital, Fudan University, Shanghai, China., Department of Urology, Hexi University Affiliated Zhangye People's Hospital, Zhangye, China.