Renal cell carcinoma (RCC) presents uncommonly in patients with a congenital solitary kidney or prior contralateral nephrectomy. The objective of this study was to compare renal function outcomes of stereotactic ablative body radiotherapy (SABR) in patients with solitary vs. bilateral kidneys.
Patients with primary RCC with ≥2 years of follow-up at 12 participating International Radiosurgery Consortium for Kidney (IROCK) institutions were included. Patients with upper tract urothelial carcinoma or metastatic disease were excluded. Renal function was measured by estimated glomerular filtration rate (eGFR). For patients where eGFR was not recorded, Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation was used to estimate eGFR based on known creatinine. Baseline characteristics and renal function outcomes were compared between solitary vs. bilateral kidneys. Multivariable logistic regression was used to identify factors predictive of eGFR decline ≥ 15 mL/min and any eGFR increase evaluated at 1-year post-SABR.
One hundred and ninety patients with solitary (n = 56) or bilateral kidneys (n = 134) underwent SABR and were followed for a median of 5.0 years (IQR: 3.4-6.8). Pre-SABR eGFR (mean ± SD) was similar in patients with solitary (61.1 ± 23.2 mL/min) vs. bilateral kidneys (58.0 ± 22.3 mL/min, p = 0.324). Mean tumor size was 3.70 ± 1.40 cm in solitary and 4.35 ± 2.50 cm in bilateral kidneys (p = 0.026). After SABR, an initial compensatory increase in eGFR was observed in both cohorts (22.7% solitary and 17.7% bilateral at 1 year). This compensatory increase persisted in patients with bilateral but not a solitary kidney (10.3% vs. 0% at 3-years and 21.1% vs. 0% at 5-years, respectively). At 5-years post-SABR, eGFR decreased by -14.5 ± 7.6 in solitary and -13.3 ± 15.9 mL/min in bilateral kidneys (p = 0.665). At all timepoints assessed, there were no significant differences in eGFR decline between solitary vs. bilateral cohorts (all p > 0.05). There were also no significant differences in post-SABR end-stage renal disease (7.1% vs. 6.7%) or dialysis (3.6% vs. 3.7%) in solitary vs. bilateral, respectively. Multivariable analysis demonstrated that increasing tumor size (OR per 1 cm: 1.57; 95% CI: 1.14-2.16, p = 0.006) and baseline eGFR (OR per 10 mL/min: 1.30; 95% CI: 1.02-1.66, p = 0.034) was more likely to be associated with eGFR decline ≥ 15 mL/min. There was no significant association between solitary vs. bilateral kidney and eGFR decline (OR: 1.22; 95% CI: 0.45-3.34, p = 0.693).
There was no observed difference between renal function outcomes in patients with a solitary vs. bilateral kidneys. While larger tumor size may increase the risk of eGFR decline post-SABR, treatment of a solitary kidney does not appear to increase the risk of renal dysfunction long-term.
International journal of radiation oncology, biology, physics. 2023 Oct 01 [Epub]
V S Tan, R J M Correa, A Warner, M Ali, A Muacevic, L Ponsky, R J Ellis, S S Lo, H Onishi, A Swaminath, Y S Kwon, S C Morgan, F Cury, B S Teh, A Mahadevan, I D Kaplan, W Chu, R Hannan, M Staehler, W Grubb, A V Louie, S Siva
London Regional Cancer Program, London, ON, Canada., Peter MacCallum Cancer Centre and Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Australia., University of Munich Hospitals, Munich, Germany., University Hospitals Cleveland Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH., GenesisCare USA, Cape Coral, FL., University of Washington School of Medicine, Seattle, WA., University of Yamanashi, Chuo, Japan., Juravinski Cancer Centre, McMaster University, Hamilton, ON, Canada., University of Texas Southwestern Medical Center, Dallas, TX., The Ottawa Hospital Cancer Center, Ottawa, ON, Canada., McGill University Health Centre, Montreal, QC, Canada., Houston Methodist Hospital, Houston, TX., NYU Langone Health Laura and Isaac Perlmutter Cancer Center, New York, NY., Beth Israel Deaconess Medical Center, Boston, MA., Sunnybrook Health Sciences Centre, Toronto, ON, Canada., Augusta University, Augusta, GA.