Metachronous oligometastatic clear cell renal cell carcinoma (ccRCC) may take many years before becoming clinically apparent. Herein we report regional lymph node recurrence of ccRCC more than two decades following radical nephrectomy.
Chromosomal microarray analysis demonstrated multiple chromosomal alterations, including 3pq deletion shared by the original and recurrent tumors, and 17p deletion containing the TP53 gene present only in the latter. Sequencing of 1550 genes revealed mutations of VHL in both the primary and metastasis and BAP1 only in the metastatic lesion. These findings genetically link the original and recurrent tumors and suggest that VHL, TP53, and BAP1 alterations played an evolutionary role in recurrence decades after initial resection.
Urology. 2023 Dec 19 [Epub ahead of print]
Robert Wang, Nicole Uzzo, Raju Chelluri, Nicholas Mackrides, Hormoz Ehya, Jianming Pei, Don A Baldwin, Mariusz A Wasik, Shuanzeng Wei, Robert Uzzo
Department of Urology, Fox Chase Cancer Center, Philadelphia, Pennsylvania, PA. Electronic address: ., Department of Urology, Fox Chase Cancer Center, Philadelphia, Pennsylvania, PA., Department of Pathology, Fox Chase Cancer Center, Philadelphia, Pennsylvania, PA., Fox Chase Cancer Center.
PubMed http://www.ncbi.nlm.nih.gov/pubmed/38128834