We sought to identify prognostic risk factors for one year recurrence in patient with renal cell carcinoma (RCC) after partial or radical nephrectomy.
We performed a retrospective study of 1,269 patients with RCC after partial or radical nephrectomy and diagnosed recurrence using Korean Renal Cancer Study Group (KRoCS) database between January 1991 and March 2017. Recurrence-free survival (RFS), and overall survival (OS) were calculated using the Kaplan-Meier method and multivariate Cox regression analysis were performed to evaluate independent prognostic factors for recurrence.
The median patient age was 56 years and median follow-up period was 67 months. Multivariable analysis demonstrated BMI greater than or equal to 23 and less than 30 (vs. BMI less than 23, hazard ratio [HR]: 0.707, P = 0.020) reduced recurrence one year postoperatively. Eastern Cooperative Oncology Group performance status (ECOG PS) greater than or equal to 1 (vs. ECOG PS 0, HR: 1.548, P = 0.007), high pathological T stage (pT2 vs. pT1, HR: 2.622, P < 0.001; pT3 vs. pT1, HR: 4.256, P < 0.001; pT4 vs. pT1, HR: 4.558, P < 0.001), and tumor necrosis (vs. no tumor necrosis, HR: 2.822, P < 0.001) were independent predictive factors for early recurrence within one year in patients with RCC. Statistically significant differences on RFS and OS were found among pathological T stages (pT2 vs. pT1; pT3 vs. pT1; pT4 vs. pT1, all P < 0.001).
This large multicenter study demonstrated ECOG PS greater than or equal to 1, high pathological T stage, tumor necrosis and BMI less than 23 were significant prognostic risk factors of early recurrence within one year in patients with RCC who underwent nephrectomy.
Journal of Korean medical science. 2024 Jan 22*** epublish ***
Changil Choi, Minyong Kang, Seong Il Seo, Jungyo Suh, Cheryn Song, Jinsoo Chung, Sung Han Kim, Jae Young Park, Eu Chang Hwang, Chang Wook Jeong, Cheol Kwak, Jung Kwon Kim, Sung-Hoo Hong
Department of Urology, Hallym University Dongtan Sacred Heart Hospital, Hwaseong, Korea., Department of Urology, Samsung Medical Center, Seoul, Korea., Department of Urology, Asan Medical Center, Seoul, Korea., Department of Urology, National Cancer Center, Goyang, Korea., Department of Urology, Korea University College of Medicine, Korea University Ansan Hospital, Ansan, Korea., Department of Urology, Chonnam National University Medical School, Chonnam National University Hwasun Hospital, Hwasun, Korea., Department of Urology, Seoul National University Hospital, Seoul, Korea., Department of Urology, Seoul National University Bundang Hospital, Seongnam, Korea., Department of Urology, The Catholic University of Korea, Seoul St. Mary's Hospital, Seoul, Korea. .