Saliby et al. show that a machine learning approach can accurately classify clear cell renal cell carcinoma (RCC) into distinct molecular subtypes using transcriptomic data. When applied to tumors biospecimens from the JAVELIN Renal 101 (JR101) trial, a benefit is observed with immune checkpoint inhibitor (ICI)-based therapy across all molecular subtypes.
Cancer cell. 2024 Mar 22 [Epub ahead of print]
Renée Maria Saliby, Chris Labaki, Tejas R Jammihal, Wanling Xie, Maxine Sun, Valisha Shah, Eddy Saad, M Harry Kane, Soki Kashima, Katherine Sadak, Talal El Zarif, Deepak Poduval, Robert J Motzer, Thomas Powles, Brian I Rini, Laurence Albiges, Sumanta K Pal, Bradley A McGregor, Rana R McKay, Sabina Signoretti, Eliezer M Van Allen, Sachet A Shukla, Toni K Choueiri, David A Braun
Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA; Center of Molecular and Cellular Oncology (CMCO), Yale University, New Haven, CT, USA., Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA; Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA., Children's Hospital of Philadelphia, Philadelphia, PA, USA., Department of Data Sciences, Dana-Farber Cancer Institute, Boston, MA, USA., Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Center of Molecular and Cellular Oncology (CMCO), Yale University, New Haven, CT, USA., Center of Molecular and Cellular Oncology (CMCO), Yale University, New Haven, CT, USA; Department of Urology, Akita University School of Medicine, Akita, Japan., Yale School of Medicine, New Haven, CT, USA., Memorial Sloan Kettering Cancer Center, New York, NY, USA; Department of Medicine, Weill Cornell Medical Center, New York, NY, USA., Barts Cancer Institute and the Royal Free Hospital, Queen Mary University of London, London, UK., Division of Hematology and Oncology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Department of Cancer Medicine, Gustave Roussy, Villejuif, France., Department of Medical Oncology, City of Hope Comprehensive Cancer Center, Duarte, CA, USA., Moores Cancer Center, University of California San Diego Health, La Jolla, CA, USA., Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA., Department of Hematopoietic Biology and Malignancy, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. Electronic address: ., Center of Molecular and Cellular Oncology (CMCO), Yale University, New Haven, CT, USA. Electronic address: .