Kidney cancer, a type of urogenital cancer, imposes a high burden on patients. Despite this, no recent research has evaluated the burden of this type of cancer in the Middle East and North Africa (MENA) region. This study explored the burden of kidney cancer from 1990 to 2019 according to age, sex and socio-demographic index (SDI). The Global Burden of Disease (GBD) 2019 data was utilized to estimate the incidence, death, and disability-adjusted life-years (DALYs) caused by kidney cancer. These estimates were reported as counts and as age-standardised rates with 95% uncertainty intervals (UIs). The estimated age-standardised incidence, mortality, and DALY rates of kidney cancer in 2019 were 3.2 (2.8-3.6), 1.4 (1.2-1.6), and 37.2 (32.0-42.6) per 100,000, respectively. Over the period from 1990 to 2019, these rates have increased by 98.0%, 48.9%, and 37.7%, respectively. In 2019, the United Arab Emirates, Qatar, and Lebanon had the largest age-standardised incidence, mortality, and DALY rates. The smallest age-standardised incidence rates were seen in Yemen, Afghanistan, and the Syrian Arab Republic. Additionally, the smallest age-standardised mortality and DALY rates were observed in the Syrian Arab Republic, Yemen, and Morocco. The highest incidence rates were found among individuals aged 75-79 in both males and females. In 2019, the MENA/Global DALY ratio exceeded one for females aged 5-19 age and males aged 5-14, compared to 1990age groups in males. The burden of kidney cancer consistently rose with increasing SDI levels from 1990 to 2019. The increasing burden of kidney cancer highlights the urgent need for interventions aimed at improving early diagnosis and treatment in the region.
Scientific reports. 2024 Jun 14*** epublish ***
Saeid Safiri, Kamaleddin Hassanzadeh, Amir Ghaffari Jolfayi, Seyed Ehsan Mousavi, Kimia Motlagh Asghari, Seyed Aria Nejadghaderi, Nima Naghdi-Sedeh, Maryam Noori, Mark J M Sullman, Gary S Collins, Ali-Asghar Kolahi
Social Determinants of Health Research Center, Department of Community Medicine, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran. ., Department of Urology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran., Student Research Committee, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Neurosciences Research Center, Aging Research Institute, Tabriz University of Medical Sciences, Tabriz, Iran., Social Determinants of Health Research Center, Department of Community Medicine, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran., HIV/STI Surveillance Research Center, and WHO Collaborating Center for HIV Surveillance, Institute for Futures Studies in Health, Kerman University of Medical Sciences, Kerman, Iran., Hematology and Oncology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran., Urology Research Center, Tehran University of Medical Sciences, Tehran, Iran., Department of Life and Health Sciences, University of Nicosia, Nicosia, Cyprus., Centre for Statistics in Medicine, NDORMS, Botnar Research Centre, University of Oxford, Oxford, UK., Social Determinants of Health Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. .