Metastatic carcinoma of presumed renal origin (rCUP) has recently emerged as a new entity within the heterogeneous entity of Cancers of Unknown Primary (CUP) but their biological features and optimal therapeutic management remain unknown. We report the molecular characteristics and clinical outcome of a series of 25 rCUP prospectively identified within the French National Multidisciplinary Tumor Board for CUP. This cohort strongly suggests that rCUP share similarities with common RCC subtypes and benefit from renal-tailored systemic treatment. This study highlights the importance of integrating clinical and molecular data for optimal diagnosis and management of CUP.
NPJ precision oncology. 2024 Jul 18*** epublish ***
Nicolas Jacquin, Ronan Flippot, Julien Masliah-Planchon, Guillaume Grisay, Riwan Brillet, Célia Dupain, Maud Kamal, Isabelle Guillou, Nadège Gruel, Nicolas Servant, Pierre Gestraud, Jennifer Wong, Vincent Cockenpot, Andreia Goncalves, Janick Selves, Hélène Blons, Etienne Rouleau, Olivier Delattre, Claire Gervais, Christophe Le Tourneau, Ivan Bièche, Yves Allory, Laurence Albigès, Sarah Watson
INSERM U830, Diversity and Plasticity of Childhood Tumors Lab, PSL Research University, Institut Curie Research Center, Paris, France., Department of Cancer Medicine, Institut Gustave Roussy, Université Paris-Saclay, Villejuif, France., Somatic Genetic Unit, Department of Genetics, Institut Curie Hospital, Paris, France., Clinical Bioinformatic Unit, Department of Diagnostic and Theragnostic Medicine, Institut Curie Hospital, Paris, France., Department of Drug Development and Innovation (D3i), Institut Curie, Paris, France., INSERM U900, CBIO-Centre for Computational Biology, Institut Curie Research Center, Mines ParisTech, Paris, France., Department of Pathology, Institut Curie Hospital, Paris, France., Department of Pathology, University Hospital of Toulouse (IUCT), Toulouse, France., Department of Biochemistry, Pharmacogenetics and Molecular Oncology, Georges Pompidou European Hospital, APHP, Paris, France., PRISM Center for personalized medicine, Gustave Roussy Cancer Center, Villejuif, France., Department of Medical Oncology, Georges Pompidou European Hospital, APHP, Paris, France., Department of Genetics, Institut Curie Hospital, INSERM U1016, Université Paris Cité, Paris, France., Department of Pathology, Institut Curie Hospital, Saint-Cloud, France. ., Department of Cancer Medicine, Institut Gustave Roussy, Université Paris-Saclay, Villejuif, France. ., INSERM U830, Diversity and Plasticity of Childhood Tumors Lab, PSL Research University, Institut Curie Research Center, Paris, France. .