Real-world data are limited on treatment sequencing and outcomes after first-line (1L) immune checkpoint inhibitor (CPI)-based combination treatment of advanced renal cell carcinoma (aRCC).
In this real-world, UK-based, retrospective study (CARINA; NCT04957160), data were obtained from hospital and electronic prescribing records. Patients were aged ≥ 18 years at aRCC diagnosis and had received 1L CPI-CPI or tyrosine kinase inhibitor (TKI)-CPI combination therapy before second-line (2L) therapy including cabozantinib. We describe treatment outcomes including 1L and 2L durations of treatment (DoT) and overall survival (OS).
Data from April 2015 to June 2022 were collected on 281 patients from nine UK centres. Median 1L DoT was 2.3 months for CPI-CPI therapy (n = 171) and 5.0 months for TKI-CPI therapy (n = 58). After 1L CPI-CPI or TKI-CPI therapy, median 2L DoT was 5.8 versus 4.2 months, respectively, for cabozantinib (n = 163), and 3.8 versus 2.4 months for other therapies (n = 118); median 2L OS was 15.2 and 15.3 months, respectively, for cabozantinib, and 14.6 and 24.2 months for other therapies.
DoT for 2L treatment was numerically better for cabozantinib than for other therapies, and after 1L CPI-CPI therapy than after 1L TKI-CPI therapy. Median OS was similar for 2L cabozantinib and other 2L therapies, and median OS for 2L cabozantinib was similar after both 1L therapy types. These results demonstrate the antitumour effect of 2L therapies, including cabozantinib, after 1L CPI-based combination treatment, regardless of whether 1L CPI-CPI or TKI-CPI therapy is used.
Clinical genitourinary cancer. 2024 Jun 26 [Epub ahead of print]
Paul Nathan, Balaji Venugopal, Jamshed Ali, Jennifer Allison, Mariangela Ceruso, Natalie Charnley, Richard Griffiths, Agnieszka Michael, Kathryn Moore, Valérie Perrot, Áine Prendergast, Anand Sharma, Bernadett Szabados, James Larkin
Department of Medical Oncology, Mount Vernon Cancer Centre, Northwood, UK. Electronic address: ., School of Cancer Sciences, Beatson West of Scotland Cancer Centre, Glasgow, UK; University of Glasgow, Glasgow, UK., School of Cancer Sciences, Beatson West of Scotland Cancer Centre, Glasgow, UK., Department of Medical Oncology, Christie NHS Foundation Trust, Manchester, UK., Medical Affairs, Ipsen Ltd., London, UK., Department of Oncology, Royal Preston Hospital, Preston, UK., Department of Medical Oncology, Clatterbridge Cancer Centre NHS Foundation Trust, Liverpool, UK., Department of Medical Oncology, Royal Surrey County Hospital NHS Foundation Trust, Guildford, UK., Nottingham Cancer Clinical Trials Team, Nottingham University Hospitals NHS Trust, Nottingham, UK., Medical Affairs Biometry, Ipsen, Boulogne-Billancourt, France., Department of Medical Oncology, Mount Vernon Cancer Centre, Northwood, UK., Barts Experimental Cancer Medicine Centre, Barts Cancer Institute, Queen Mary University of London, London, UK., Urology and Skin Units, Royal Marsden NHS Foundation Trust, London, UK.