Renal cell carcinoma (RCC) is the seventh most common cancer in the United States; clear cell RCC (ccRCC) is the most common subtype. We report a case of spontaneous regression of metastatic ccRCC and discuss possible underlying mechanisms informed by a literature review. While regression of metastatic RCC has been described following nephrectomy or treatment of the primary tumor, spontaneous regression is rare. Postulated underlying causes include tumor necrosis and immune-mediated responses. Of 29 identified cases of spontaneous regression, only ours occurred after only a biopsy. Better understanding of the pathophysiology of spontaneous regression in RCC will improve its management.
Urology case reports. 2024 Oct 09*** epublish ***
Anoushka Mullasseril, Anh B Lam, Alekhya Mitta, Daniel Morton, Andrew McIntosh, Sanjay Patel, Theresa Thai, Anand Annan, Adanma Ayanambakkam
Department of Internal Medicine, University of Oklahoma Health Sciences, Oklahoma City, OK, USA., Department of Radiation Oncology, University of Oklahoma Health Sciences, Oklahoma City, OK, USA., Department of Pediatrics, University of Oklahoma Health Sciences, Oklahoma City, OK, USA., Stephenson Cancer Center, University of Oklahoma Health Sciences, Oklahoma City, OK, USA., Department of Pathology, University of Oklahoma Health Sciences, Oklahoma City, OK, USA.