The rising incidence of renal cell carcinoma (RCC) is a significant concern in cancer research. This study analyses the characteristics of RCC patients based on their socio-professional category and explores the role of chlorinated solvents as a risk factor.
A multicentre, descriptive epidemiological study was conducted using the UroCCR database. All patients from participating centres who had been diagnosed with RCC between July 2021 and February 2023, as well as those seen for follow-up consultation during this period, were included. Patients were categorised into 5 socio-professional groups based on INSEE's Profession and Social Categories classification. The characteristics and risk factors of RCC for each group were compared. Binary logistic regression was used to study the exposure to chlorinated solvents and risk factors for clear cell RCC (ccRCC).
A total of 1252 patients were included. Males made up 69.6% of the population. The median age was 64 years, and 87% of the patients had at least one RCC risk factor. ccRCC, papillary, and chromophobe types accounted for 78%, 14.9%, and 8.5% of the population, respectively. The median tumor size was 4.5 cm (SD = 3.3). Farmers had a higher prevalence of ccRCC (91.3%; p = 0.05) and larger tumors (median = 6 cm SD = 3.23; p = 0.038) than patients from other populations. Smoking and obesity rates were lower (10.1%; p < 0.001; 15.9%, p = 0.018, respectively), but exposure to chlorinated solvents was higher (50.7%; p < 0.001). Exposure to chlorinated solvents was independently associated with higher TNM stages (p = 0.044, OR = 1.41 CI (1.01; 1.96)). Obesity and exposure to chlorinated solvents were independent risk factors for ccRCC (p = 0.006, OR = 1.6 CI (1.1;2.2) and p = 0.028, OR = 1.6 CI (1.1;2.6), respectively).
This study shows the influence of socio-professional categories on exposure to RCC risk factors and tumor characteristics. In particular, farmers stood out from the rest of the study population. Their significant exposure to chlorinated solvents could be an interesting factor to investigate.
World journal of urology. 2024 Nov 21*** epublish ***
Matthieu Ferragu, Jean-Christophe Bernhard, Alexis Fontenil, Julien Guillotreau, Frédéric Panthier, Nicolas Branger, Olivier Belas, Jean-Jacques Patard, François Audenet, Louis Surlemont, Richard Mallet, Thibaut Waeckel, Pierre Bigot
Department of Urology, Angers University Hospital, Angers, France. ., Department of Urology, Bordeaux University Hospital, Bordeaux, France., Department of Urology, Nîmes University Hospital, Nîmes, France., Department of Urology - Pasteur Clinic Toulouse, Toulouse, France., Department of Urology, Tenon Hospital, Paris, France., Department of Urology - Paoli Calmettes Institute, Marseille, France., Pôle Santé Sud - Private Clinic, Le Mans, France., Department of Urology, Mont-de-Marsan Hospital, Mont-de-Marsan, France., Department of Urology, Hôpital Européen Georges Pompidou, Paris, France., Department of Urology, Rouen University Hospital, Rouen, France., Department of Urology, Francheville Polyclinic, Francheville, France., Department of Urology, Caen Normandy University Hospital, Caen, France., Department of Urology, Angers University Hospital, Angers, France.