Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, Md. International Agency for Research on Cancer, Lyon, France; The Tisch Cancer Institute, Mount Sinai School of Medicine, New York; International Prevention Research Institute, Lyon, France; Stewart Exposure Assessments, LLC, Arlington, Va, and Formerly of the Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, Md; Institute of Carcinogenesis, Cancer Research Centre, Moscow, Russia; Department of Preventive Medicine, Faculty of Medicine, Palacky University, Olomouc, Czech Republic; Institute of Hygiene and Epidemiology, First Faculty of Medicine Charles University, Prague, Czech Republic; Department of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute, Brno, Czech Republic; Department of Epidemiology, Nofer Institute of Occupational Medicine, Lodz, Poland; The National Institute of Public Health, Bucharest, Romania; Department of Chemical Hazards, Nofer Institute of Occupational Medicine, Lodz, Poland; and Department of Urology, First Faculty of Medicine Charles University and General Teaching Hospital, Prague, Czech Republic.
To investigate whether occupational exposure to polycyclic aromatic hydrocarbons and certain plastic monomers increased renal cell carcinoma (RCC) risk.
Unconditional logistic regression was used to calculate RCC risk in relation to exposure.
No association between RCC risk and having ever been occupationally exposed to any polycyclic aromatic hydrocarbons or plastics was observed. Duration of exposure and average exposure also showed no association with risk. Suggestive positive associations between RCC risk and cumulative exposure to styrene (P-trend = 0.02) and acrylonitrile (P-trend = 0.06) were found. Cumulative exposure to petroleum/gasoline engine emissions was inversely associated with risk (P-trend = 0.02).
Results indicate a possible association between occupational styrene and acrylonitrile exposure and RCC risk. Additional studies are needed to replicate findings, as this is the first time these associations have been reported and they may be due to chance.
Written by:
Karami S, Boffetta P, Brennan P, Stewart PA, Zaridze D, Matveev V, Janout V, Kollarova H, Bencko V, Navratilova M, Szeszenia-Dabrowska N, Mates D, Gromiec JP, Sobotka R, Chow WH, Rothman N, Moore LE.
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Reference: J Occup Environ Med. 2011 Feb;53(2):218-223.
doi: 10.1097/JOM.0b013e31820a40a3
PubMed Abstract
PMID: 21270648
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