Department of Urology "U. Bracci", University Sapienza of Rome, Viale Policlinico 155, 00161 Rome, Italy.
We address whether rational and significant clinical data exist on using angiogenic targeted therapies as neoadjuvant or adjuvant options to nephrectomy in non-metastatic RCC.
We reviewed the recent international literature by carrying out a PUBMED search.
Neoadjuvant: a possible indication for a neoadjuvant targeted therapy approach is to facilitate surgery, reducing risks for patients and increasing the possibility of removing the mass and improving oncological results. Adjuvant: three major phase III clinical trials are currently ongoing. The ASSURE trial (1 year on oral sunitinib, sorafenib or placebo), the SORCE trial (3 years on placebo versus 1 year on sorafenib, followed by 2 years on placebo versus 3 years on sorafenib), and the S-TRAC trial (1 year on sunitinib or placebo) analyze patients who are at high risk of relapse.
Rationale and needs for the neoadjuvant or adjuvant use of targeted therapies in RCC are relevant. Significant phase III trials on the adjuvant use of targeted therapy in RCC are ongoing.
Written by:
Sciarra A, Cattarino S, Salciccia S, Alfarone A, Gentilucci A, Parente U, Mariotti G, Innocenzi M, Gentile V. Are you the author?
Reference: Crit Rev Oncol Hematol. 2011 Mar 7. Epub ahead of print.
doi: 10.1016/j.critrevonc.2011.02.003
PubMed Abstract
PMID: 21388825
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