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EAU 2011 - Head-to-head comparison of the most relevant integrated prognostic systems predicting cancer-specific survival in clear cell renal cell carcinoma - Session Highlights

VIENNA, AUSTRIA (UroToday.com) - In the past 10 years four major prognostic systems had been published to predict outcome of non-metastatic kidney cancer: the Kattan nomogram, the Mayo Clinic Stage, Size, Grade and Necrosis (SSIGN), the University of Los Angeles Integrated Staging System (UISS) and the Karakiewicz nomogram.

The authors analyzed 1,871 patients with kidney cancer from 16 academic centers to compare the performance of the Karakiewicz nomogram, the SSIGN score and the UISS to predict cancer-specific survival (CSS). At a median follow-up of 40 months, 15% of patients had died from kidney cancer and 7% of patients from other causes. The AUCs for 5-year CSS were 88.8 for the Karakiewicz nomogram, 84.1 for the UISS and 82.5 for the SSIGN. The authors concluded that the Karakiewicz nomogram performed slightly better than SSIGN and UISS. 

The investigated prognostic systems are restricted to patients with clear cell kidney cancer. Until today, the impact of these prognostic systems on adjuvant therapy and/or follow-up is rather limited.

 

Presented by Vincenzo Ficarra, MD, et al. at the 26th Annual European Association of Urology (EAU) Congress - March 18 - 21, 2011 - Austria Centre Vienna, Vienna, Austria


Reported for UroToday by Christian Doehn, MD, PhD, Department of Urology, University of Lübeck Medical School, Lübeck Germany.


 

The opinions expressed in this article are those of the UroToday.com Contributing Medical Editor and do not necessarily reflect the viewpoints of the European Association of Urology (EAU)



 



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