The authors analyzed 2,570 patients with kidney cancer (median age 61 years, male to female ratio 1.6) from 7 centers to validate the Karakiewicz nomograms. At a median follow-up of 46 months, 305 patients had died from kidney cancer and another 155 patients from other causes. The 1-, 3-, and 5-year cancer-specific survival rates (CSSs) were 95%, 88% and 85% respectively. The corresponding results for overall survival (OS) were 93%, 84% and 79% .The c-indexes for CSS was 0.776 (95% confidence interval (CI) 0.741-0.811) for the preoperative nomogram and 0.84 (95% CI 0.811-0.868)) for the postoperative nomogram. The authors concluded that the postoperative nomogram performed better than the preoperative nomogram.
It is not surprising that postoperative parameters provide better information on outcome. The Karakiewicz nomogram is useful and can be applied in adjuvant therapy trials.
Presented by Luca Cindolo, MD, FEBU, et al. at the 26th Annual European Association of Urology (EAU) Congress - March 18 - 21, 2011 - Austria Centre Vienna, Vienna, Austria
Reported for UroToday by Christian Doehn, MD, PhD, Department of Urology, University of Lübeck Medical School, Lübeck Germany.
View EAU 2011 Annual Meeting Coverage
