Sarah Cannon Research Institute, Nashville, TN, USA.
To evaluate the activity of panobinostat in refractory renal carcinoma.
Patients with advanced clear cell renal carcinoma who had received previous therapy with at least one angiogenesis inhibitor and one mTOR inhibitor were treated with panobinostat 45 mg orally twice a week, and were reevaluated after 8 weeks.
Twenty patients were treated with no objective responses. All patients progressed or stopped treatment prior to the 16-week reevaluation. Panobinostat was generally well-tolerated.
Panobinostat had no activity in this group of patients with refractory renal carcinoma. Further development of panobinostat in renal carcinoma is not recommended.
Written by:
Hainsworth JD, Infante JR, Spigel DR, Arrowsmith ER, Boccia RV, Burris HA. Are you the author?
Reference: Cancer Invest. 2011 Aug;29(7):451-5.
doi: 10.3109/07357907.2011.590568
PubMed Abstract
PMID: 21696296
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