Department of Pathology, Hôpital Necker-Enfants Malades, AP-HP, Paris.
Université Paris Descartes, Paris Department of Genetics, Institut Curie, Paris; Department of Pathology, Hôpital Saint-Joseph, Paris; Department of Pathology, Hôpital Cochin, AP-HP, Paris; Université Pierre et Marie Curie, Paris; Department of Pathology, Hôpital Tenon, AP-HP, Paris, France.
To report clinicopathological and genomic characteristics of (ccpRCC), a rare, recently characterized renal tumour entity.
Twenty-four renal tumours identified as ccpRCC were collected. Data from comparative genomic hybridization on microarrays (array-CGH) were obtained for seven of these. Most tumours (58%) occurred in the absence of renal disease. Mean patient age was 58.1 years. Tumours were small (mean size: 2.4 cm) and classified as pT1. Histological characteristics consisted of tubules and papillae lined by a single layer of small clear cells harbouring low-grade nuclei (Fuhrman grades 1 or 2). Architectural variations, with compact areas (41% of cases) and a micro- or macrocystic pattern (67% of cases) were observed frequently. Immunostaining demonstrated diffuse, strong expression of cytokeratin 7 and vimentin, whereas CD10, racemase, RCC antigen, translocation factor E3, TFE3 and translocation factor EB were consistently negative. In seven tumours, array-CGH detected no chromosomal imbalances.
Clear-cell papillary renal cell carcinoma (ccpRCC) were differentiated from other renal neoplasms by a specific constellation of histopathological and immunohistochemical features, without characteristic genomic imbalances. Clinical, histopathological and genomic data suggested that these tumours have a low potential for malignancy.
Written by:
Adam J, Couturier J, Molinié V, Vieillefond A, Sibony M. Are you the author?
Reference: Histopathology. 2011 Jun;58(7):1064-71.
doi: 10.1111/j.1365-2559.2011.03857.x
PubMed Abstract
PMID: 21707708
UroToday.com Renal Cancer Section
