Howard Hughes Medical Institute (HHMI), 4000 Jones Bridge Road, Chevy Chase, MD 20815, USA.
Department of Medical Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, 450 Brookline Avenue, Boston, MA 02215, USA.
Ninety percent or more of kidney cancers are believed to be of epithelial cell origin, and are referred to as renal cell carcinoma (RCC), which are further subdivided based on histology into clear-cell RCC (75%), papillary RCC (15%), chromophobe tumor (5%), and oncocytoma (5%). Some genes confer an increased risk of these various histologic RCC subtypes. In practice, there is some overlap among the histologic subtypes, and there are some shared molecular features among these tumor types. This review focuses primarily on the most common form of RCC, clear-cell renal carcinoma, noting some recent advances in the other histologic subtypes.
Written by:
Li L, Kaelin WG Jr. Are you the author?
Reference: Hematol Oncol Clin North Am. 2011 Aug;25(4):667-86.
doi: 10.1016/j.hoc.2011.04.004
PubMed Abstract
PMID: 21763962
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