Division of Hematology & Oncology and Rush University Cancer Center, Rush University Medical Center, Chicago, IL, USA.
Vaccines have shown promise for the prevention and treatment of solid tumors. Colorectal cancer and renal cell carcinoma are common malignancies that may be amenable to vaccine strategies. This review summarizes target antigens in colorectal and renal cell carcinoma, discusses some of the vaccine approaches in development, and details the results of pivotal phase III trials evaluating therapeutic vaccines in patients with advanced colorectal and renal cell carcinoma. Finally, some of the challenges with vaccine development for colorectal and renal cell carcinoma are described.
Written by:
Kabaker K, Shell K, Kaufman HL. Are you the author?
Reference: Cancer J. 2011 Sep;17(5):283-93.
doi: 10.1097/PPO.0b013e318232ff44
PubMed Abstract
PMID: 21952277
UroToday.com Renal Cancer Section
