Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Fumarate hydratase (FH) is a tumor suppressor, but how it acts is unclear. Two reports in this issue of Cancer Cell reveal that FH deficiency leads to succination of Keap1, stabilization of Nrf2, and induction of stress-response genes including HMOX1, which is important for the survival of FH-deficient cells.
Written by:
Kinch L, Grishin NV, Brugarolas J. Are you the author?
Reference: Cancer Cell. 2011 Oct 18;20(4):418-20.
doi: 10.1016/j.ccr.2011.10.005
PubMed Abstract
PMID: 22014567
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