Twelve-year survival after multiple recurrences and repeated metastasectomies for renal cell carcinoma - Abstract

BACKGROUND: Metastatic renal cell carcinoma (RCC) presents a therapeutic challenge for clinicians because of the unpredictable clinical course, resistance to chemotherapy or radiotherapy and the limited response to immunotherapy.

PATIENTS AND METHODS: We report a case of a 62-year-old woman who underwent nephrectomy for T4N0 RCC, clear cell type, Fuhrman grade 3/4 in 1999. The patient subsequently had multiple tumor recurrences.

RESULTS: The patient underwent eight metastasectomies, including multiple partial left nephrectomies, right adrenalectomy, a complete left nephrectomy, and distal pancreatectomy. She remains well and tumor free 12 years after initial diagnosis.

CONCLUSION: Repeated resections after initial metastasectomy can be carried out safely and provide long-term survival in selected patients with recurrent metastasis from RCC. The findings from our case indicate that close follow-up for the early detection of recurrence and complete resection of metastases can improve the results after repeated resection.

Written by:
Wang J, Talmon GA, Feloney M, Morris MC.   Are you the author?
Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE 68198-7680, USA.

Reference: World J Surg Oncol. 2011 Nov 28;9(1):155.
doi: 10.1186/1477-7819-9-155

PubMed Abstract
PMID: 22123271

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