Pediatric renal cell carcinoma (RCC) is rare and different from adult RCC.
Although target agents have recently been introduced, allogeneic hematopoietic stem cell transplantation exploiting graft-versus-tumor effect still remains an important treatment option for metastatic RCC. A 2-year-old male with RCC developed hepatic metastases 6 months following radical nephrectomy and subsequent cytokine therapy. Allogeneic reduced-intensity stem cell transplantation (RIST) with early withdrawal of immunosuppression and delayed donor lymphocyte infusions was performed. A second transplantation was undertaken following marrow aplasia. Now he remains progression-free with regression of hepatic metastases 5.7 years after RIST, along with complete donor chimerism.
Written by:
Baek HJ, Han DK, Hwang TJ, Bae SH, Choi YD, Kook H. Are you the author?
Division of Pediatric Hematology and Oncology, Department of Pediatrics, Chonnam National University Hwasun Hospital, Chonnam National University Medical School, Gwangju, Korea.
Reference: Pediatr Blood Cancer. 2012 Jan 9. Epub ahead of print.
doi: 10.1002/pbc.24074
PubMed Abstract
PMID: 22231905
