BACKGROUND:Renal cell carcinoma is the seventh leading cause of cancer deaths.
Studies have shown patients with solitary osseous metastases have a better prognosis; however, methods of resection are not well defined. The purpose of this study was to review factors associated with survival and assess the impact of wide versus intralesional management on function and disease-specific outcomes in patients with renal cell carcinoma metastases.
METHODS:Sixty-nine patients with 86 osseous renal cell metastases were reviewed. Potential factors associated with survival were evaluated with Kaplan-Meier curves. ANOVA was performed to compare means between groups.
RESULTS:One year survival for the group was 77% and 32.5% at 5 years. The absence of metastatic disease at presentation, nephrectomy, and pre-operative status were associated with improved survival. There was a lower rate of local recurrence with wide resection (5%) versus intralesional procedures (27%).
CONCLUSIONS: Improved pre-operative status, nephrectomy, and metachronous lesions had better overall survival. Wide resection results in decreased local recurrence and revision surgeries. However, it did not reliably predict improved survival. Our recommendation is for individual evaluation of each patient with osseous renal cell carcinoma metastases. Wide excision may be used for resectable lesions to prevent local progression and subsequent surgeries.
Written by:
Evenski A, Ramasunder S, Fox W, Mounasamy V, Temple HT. Are you the author?
Department of Orthopaedics, University of Pennsylvania, Philadelphia, Pennsylvania.
Reference: J Surg Oncol. 2012 May 23. Epub ahead of print.
doi: 10.1002/jso.23134
PubMed Abstract
PMID: 22623216
UroToday.com Renal Cancer Section
