Aims: To date, only limited information is available on the prognostic significance of the presence and extent of histological tumour necrosis with regard to papillary renal cell carcinoma (RCC) types 1 and 2 subclassification.
Thus, the aim of this study was to evaluate the prognostic impact of these pathological features on the clinical outcome in papillary subtypes.
Methods and Results: The influence of histological tumour necrosis on the clinical outcome in 177 patients with papillary RCC was evaluated. For papillary subtype 1, the presence of histological tumour necrosis was an independent negative prognostic factor for disease-free survival (P = 0.039), and a greater extent of necrosis (>20%) was significantly associated with both poor disease-free and overall survival (P = 0.033 and P = 0.041, respectively). Regarding papillary subtype 2, neither the presence nor extent of histological tumour necrosis was a statistically significant negative prognostic factor.
Conclusion: Our findings suggest that the presence and extent of histological tumour necrosis are independent prognosticators in papillary RCC subtype 1, but not in papillary subtype 2. Thus, previously reported conflicting data regarding the prognostic impact of tumour necrosis in papillary RCC might be explained, in part, by heterogeneous subtypes.
Written by:
Pichler M, Hutterer GC, Chromecki TF, Pummer K, Mannweiler S, Zigeuner R. Are you the author?
Division of Oncology, Department of Internal Medicine, Medical University of Graz (MUG), Graz, Austria; Department of Urology, Medical University of Graz (MUG), Graz, Austria; Institute of Pathology, Medical University of Graz (MUG), Graz, Austria.
Reference: Histopathology. 2013 Jan;62(2):219-28.
doi: 10.1111/j.1365-2559.2012.04328.x
PubMed Abstract
PMID: 22957986
UroToday.com Renal Cancer Section
