BACKGROUND: We retrospectively investigated short-term functional and oncological outcomes of partial nephrectomy (PN) for the anatomically or functionally solitary kidney in patients with renal cell carcinoma.
METHODS: Between 1993 and 2011, 193 partial nephrectomies were performed and 16 (8.3 %) had an imperative indication in our institution. The patients' characteristics, peri- and postoperative complications, surgical margin status and postoperative changes in estimated glomerular filtration rates (eGFR) were assessed.
RESULTS: The median follow-up period was 31.2 months and median age was 69.5 years. Open and laparoscopic PN were performed for 13 and 2 patients, respectively. One patient received ex-vivo PN followed by autotransplantation. There was no case with a positive surgical margin. All patients survived at the final day of observation. Median preoperative eGFR was 48.67 mL/min/1.73 m2 and the reduction rate of eGFR at 3 months after operation was 20.9 % (0-50.2). Three patients (18.8 %) required temporary hemodialysis after operation and all these patients had stage 4 chronic kidney disease (CKD) before operation. Only one patient needed chronic hemodialysis at 8 months after operation.
CONCLUSIONS: PN can be performed safely and provides feasible functional and oncological outcomes. Preoperative CKD stage 4 patients may have a risk of temporary hemodialysis in the perioperative period.
Written by:
Maehana T, Tanaka T, Kitamura H, Masumori N, Tsukamoto T. Are you the author?
Department of Urology, Sapporo Medical University School of Medicine, S-1, W-16, Chuo-ku, Sapporo, Hokkaido, 060-8543, Japan.
Reference: Int J Clin Oncol. 2012 Oct 12. Epub ahead of print.
doi: 10.1007/s10147-012-0484-7
PubMed Abstract
PMID: 23065115
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